Inclusion Criteria

Adult male or female aged > 18 years and < 75 years.

  • One or more prior corneal transplants to one or both eyes with loss of vision due to transplant failure.
  • Being considered for full-thickness corneal re-transplantation.
  • Neo-vascularisation of the current corneal transplant limited to 1 quadrant or less.
  • Primary eye disease due to a non-infectious cause.
  • Willing and able to give consent to trial participation.

Exclusion Criteria

Current or prior infectious eye disease within the last 3 months prior to the first allo-BM-MSC infusion.

  • Neo-vascularisation of the cornea involving 2 or more quadrants.
  • Chronic lung or liver disease.
  • Active cancer or history of cancer other than non-melanoma skin cancer within the past 5 years.
  • Positive serological test for HIV
  • Current prescription of immunosuppressive medication other than topical corticosteroid drops.
  • Documented intolerance of or allergic reaction to mycophenolate mofetil.
  • Pregnancy or lactating