National Eye Research Centre, U.K. funds VISICORT exploitation research

VISICORT PIs Professors Malcolm Walkinshaw (University of Edinburgh) and Conor Murphy (RCSI, Royal College of Surgeons in Ireland) and Dr Karl Burgess and Lisa Imrie were recently awarded funding (£66,500) from the National Eye Research Centre (U.K.), (NERC) for the research project: A Multi-omics approach to eye tissue characterisation in Keratoconus & Fuch’s Dystrophy patients. Congratulations to the team and in particular to Lisa who has pioneered the use of a multi-omics approach in analysing eye tissues.

The fully-funded PhD project will examine two common conditions affecting the cornea – keratoconus and Fuch’s endothelial corneal dystrophy (FECD). Lisa, a proteomics specialist will identify families of proteins, lipids, and metabolites (“multi-omics”) using mass spectrometry – an instrumental method looking at the chemical composition of substances. Analysing different eye tissue samples from the same patient at different time points will allow for a better understanding of how these diseases develop and progress. The research will benefit from access to a collection of more than 3000 biosamples from people with either keratoconus or FECD that have been enrolled in the VISICORT cross-sectional analysis study, where the different eye tissues have been stored and linked to a clinical database with detailed information about each patient.

“It is really gratifying to see how the VISICORT project has led to the development of a new and exciting approach for analysing the invaluable collection of our biological samples. We can look forward to being able to identify important new and medically important biomarkers from Lisa’s VISICORT-inspired PhD.”

Professor Malcolm Walkinshaw, University of Edinburgh

The 3-year project will also draw upon the VISICORT network of clinical and scientific experts in the field of corneal disease. This work will identify signalling and metabolic pathways that are clearly implicated in keratoconus and FECD disease aetiology. Lisa aims to get started on October 1, 2020.

NERC, the National Eye Research Centre (https://www.nercuk.org/) is a charitable incorporated organisation and community of donors, volunteers, researchers, healthcare professionals, and fundraisers working together towards a common goal of beating sight loss forever. They fund pioneering research into the causes of eye disease to develop better prevention methods and more effective treatments for children and adults. NERC has been able to invest over £17 million in research projects that are bringing scientists ever closer to answering some of the most fundamental questions about eye health and eye disease.